Posts Tagged ‘aerobic exercise’

Exercise May Boost Recovery of Motor Function in Stroke Patients

Aerobic exercise improves cardiorespiratory fitness in patients with stroke, and also may have a beneficial effect on their brain function as well as help them improve recovery of motor function, according to the results of a new study.

Aerobic exercise elicits a variety of positive effects in people of all ages.

Recently, researchers have found significant improvements in aerobic exercise capacity among stroke patients who underwent a structured cycling exercise program.

“The effects of aerobic exercise may serve to prime the central nervous system in individuals with stroke to create an environment optimal for neuroplasticity (the brain’s ability to reorganize itself),” Susan Linder, a research physical therapist at the Cleveland Clinic in Cleveland, told a packed poster session at the American Academy of Neurology annual meeting in Philadelphia.

“Our work in individuals with Parkinson’s disease indicates that forced exercise administered via a motor-assisted stationary bicycle results in increased cortical activation and improved motor and non-motor function when compared to voluntary exercise,” Linder said.

The precise mechanism responsible for improvements in patients with Parkinson disease is unknown, but Cleveland Clinic researchers hypothesize that aerobic exercise increases concentrations of brain-derived neurotrophic factor (BDNF), a protein released in the CNS that facilitates long-term enhancement of signals within the brain and promotes growth of dendrites, which are branched filaments in nerve cells.

“Pairing aerobic exercise with upper extremity repetitive task practice in individuals with stroke may exploit the neuroplasticity properties associated with BDNF and optimize motor learning,” said Linder.

IMPROVED MOTOR OUTCOMES

She reported the results of a study of 14 patients who had a stroke within the previous 6 to 12 months.

They were randomized into 3 groups.

One group performed a 45-minute session of aerobic exercise at a forced rate within their heart rate range on an exercise cycle, followed by 45 minutes of repetitive task practice with hands or arms.

The second group performed the same exercises but exercised at their own rate.

The third group did no aerobic exercise and performed two 45-minute sessions of upper extremity exercises.

All participants exercised 3 times a week for 8 weeks, and they were able to complete the cycling protocol with modifications for fatigue.

All were able to achieve hundreds of repetitions with repetitive task practice.

“Motor outcomes are trending in a positive direction for all groups, but the group who performed forced rate exercise displayed the most consistent improvements,” Linder said, noting that the control group had twice the amount of time doing upper extremity exercises.

“We also saw improvement in depression and quality of life in the aerobic exercise group trending toward favorable.”

Linder added, “We know that aerobic exercise can help stroke patients’ physical fitness.

Is there a neuroplasticity effect?

We hope that the byproduct of aerobic exercise is reduced amounts of rehabilitation time as well as doses that lead to better motor outcomes for stroke patients.”

The Cleveland Clinic researchers are expanding their research to include 75 patients and will add in neurological examinations.

Said Linder, “We plan to look at changes in structure of connectivity within the brain using imaging and resting MRI to see whether areas of brain regrow and improve neural connections with aerobic exercise.”